2,2'-Bipyridine

Names

[ CAS No. ]:
366-18-7

[ Name ]:
2,2'-Bipyridine

[Synonym ]:
bipyridine
2-(2-pyridyl)pyridine
α,α'-dipyridine
EINECS 206-674-4
2,2’-Bipyridyl
dipyridyl
2,2'-Bipyridin
2,2-BIPYRIDINE
2-pyridin-2-ylpyridine
2,2′-bipyridine
2,2′-bipyridyl
[2,2]Bipyridinyl
α,α'-bipyridine
2,2′ bipyridine
2,2’-bipyridine
2,2'-BIPYRIDINE-3,3'-DIOL
2,2'-Bipyridyl
2,2'-Bipyridine
2,2'-Dipyridyl
bipyridyl
bpy
2,2‘-Dipyridyl
2,2`-Bipyridyl
Dipyridyl, 2,2'
MFCD00006212
2,2′-bipyridinyl
2,2'-dipyridine
2,2-Dipyridyl
α,α'-dipyridyl
bipy
α,α'-Bipyridyl

Biological Activity

[Description]:

2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
272.5±0.0 °C at 760 mmHg

[ Melting Point ]:
70-73 °C(lit.)

[ Molecular Formula ]:
C₁₀H₈N₂

[ Molecular Weight ]:
156.184

[ Flash Point ]:
107.2±12.0 °C

[ Exact Mass ]:
156.068741

[ PSA ]:
25.78000

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.581

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive.

[ Water Solubility ]:
5.5 g/L 22 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1750000

CHEMICAL NAME :: 2,2'-Bipyridine

CAS REGISTRY NUMBER :: 366-18-7

BEILSTEIN REFERENCE NO. :: 0113089

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H8-N2

MOLECULAR WEIGHT :: 156.20

WISWESSER LINE NOTATION :: T6NJ B- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes in urine composition Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 131 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8000 mg/kg/40W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 60 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 14500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,223,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84441 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84441 No. of Facilities: 461 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 3684 (estimated) No. of Female Employees: 886 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311

[ Precautionary Statements ]:
P280-P301 + P310-P312

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S36/37-S45-S36/37/39-S26

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
DW1750000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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