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Kynuramine dihydrochloride

Names

[ CAS No. ]:
36681-58-0

[ Name ]:
Kynuramine dihydrochloride

[Synonym ]:
1-Propanone, 3-amino-1-(2-aminophenyl)-, hydrochloride (1:2)
3-Amino-1-(2-aminophenyl)-1-propanone dihydrochloride
MFCD28384025

Biological Activity

[Description]:

Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Metabolic Disease

[In Vitro]

Kynuramine inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro[2]. Kynuramine has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries[2]. Kynuramine (20 μg/mL) frequently causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation[2].

[In Vivo]

Kynuramine may serve a physiological role in the modulation of female sexual behavior[3]. Kynuramine increases heart rate and blood pressure in pithed rats[4]. Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular administration. Result: Produced facilitation of lordosis behavior.

[References]

[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.

[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6.

[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51.

[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H14Cl2N2O

[ Molecular Weight ]:
237.13

[ Exact Mass ]:
236.048325

Related Compounds