l-nio dihydrochloride

Names

[ Name ]:
l-nio dihydrochloride

[Synonym ]:
L-NIO,2HCL
L-NIO DIHYDROCHLORIDE
(E)-N-(1-Aminoethylidene)-L-ornithine dihydrochloride
L-NIO
L-N5-(1-Iminoethyl)-ornithine dihydrochloride
L-Ornithine, N-(1-aminoethylidene)-, (E)-, hydrochloride (1:2)

Biological Activity

[Description]:

L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO induces a consistentfocal ischemic infarctin rats[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[Target]

Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]

[In Vitro]

[In Vivo]

L-NIO (2.0 μmol, 3 days post-ischemia) causes focal cerebral ischemia in the adult rat brain[2].

[References]

[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9.

[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.

Chemical & Physical Properties

[ Density]:
1.26 g/cm3

[ Boiling Point ]:
358.9ºC at 760 mmHg

[ Melting Point ]:
225-226ºC

[ Molecular Formula ]:
C₇H₁₅N₃O₂

[ Molecular Weight ]:
173.21

[ Flash Point ]:
170.9ºC

[ Exact Mass ]:
245.069778

[ PSA ]:
99.20000

[ LogP ]:
2.56020

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S24/25

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%