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BigLEN(rat) TFA

Names

[ CAS No. ]:
369377-66-2

[ Name ]:
BigLEN(rat) TFA

Biological Activity

[Description]:

BigLEN(rat), one of the most abundant peptides in brain, is a potent GPR171 agonist, with an EC50 of 1.6 nM[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

BigLEN-GPR171 system plays an important role in regulating feeding and metabolism in mice[1][2].

[References]

[1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.

[2]. Ivone Gomes, et al. GPR171 Is a Hypothalamic G Protein-Coupled Receptor for BigLEN, a Neuropeptide Involved in Feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₆H₁₂₈N₂₄O₂₃

[ Molecular Weight ]:
1745.98

Related Compounds