Alpha-Hydroxyalprazolam

Names

[ Name ]:
Alpha-Hydroxyalprazolam

[Synonym ]:
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-1-methanol, 8-chloro-6-phenyl-
MFCD00171226
4h-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine-1-methanol, 8-chloro-6-phenyl-
(8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol
Alpha-Hydroxyalprazolam

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
556.1±60.0 °C at 760 mmHg

[ Melting Point ]:
129-134ºC

[ Molecular Formula ]:
C₁₇H₁₃ClN₄O

[ Molecular Weight ]:
324.764

[ Flash Point ]:
290.1±32.9 °C

[ Exact Mass ]:
324.077789

[ PSA ]:
60.55000

[ LogP ]:
1.70

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.730

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium.

Methods Mol. Biol. 603 , 89-105, (2010)

We describe a single method for the detection and quantitation of 13 commonly prescribed benzodiazepines and metabolites: alpha-hydroxyalprazolam, alpha-hydroxyethylflurazepam, alpha-hydroxytriazolam,...

Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS).

Methods Mol. Biol. 603 , 75-87, (2010)

The benzodiazepine assay utilizes gas chromatography-mass spectrometry (GC-MS) for the analysis of diazepam, nordiazepam, oxazepam, temazepam, lorazepam, alpha-hydroxyalprazolam, and alpha-hydroxytria...

[Pharmacological studies on alprazolam, and its main metabolites, alpha-OH-alprazolam and HB compound (author's transl)].

Igaku Kenkyu. 50(7) , 495-507, (1980)