1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane

Names

[ Name ]:
1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane

[Synonym ]:
Phenol, 4-[3-(4-hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)-
4-[3-(4-Hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)phenol

Biological Activity

[Description]:

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Metabolic Disease

[References]

[1]. Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018 Oct;130:37-42.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
490.3±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₆O₃

[ Molecular Weight ]:
326.429

[ Flash Point ]:
250.3±27.3 °C

[ Exact Mass ]:
326.188202

[ PSA ]:
49.69000

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ Hazard Codes ]:
Xi