[Hyp<sup>3</sup>]Bradykinin

Names

[ Name ]:
[Hyp<sup>3</sup>]Bradykinin

[Synonym ]:
[Hyp(3)]-bradykinin
N-(Diaminomethylene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-N-(diaminomethylene)-L-ornithine
[HYP3]-BRADYKININ (HUMAN) 2ACOH 3H2O
bradykinin,hydroxy-Pro(3)
L-Ornithine, N-(diaminomethylene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-N-(diaminomethylene)-
[HYP3]-BRADYKININ
BRADYKININ [HYP3]
[HYP3]-BRADYKININ (HUMAN)
L-Arg-L-Pro-4-Hydroxy-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-OH
Bradykinin[Hyp3]

Biological Activity

[Description]:

[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

[In Vitro]

[Hyp3]-Bradykinin is as active as native Bradykinin in its ability to bind to bovine uterine myometrium and in its potency on the isolated rat uterus[1].

[References]

[1]. R Dengler, et al. [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin interact with B2-bradykinin receptors and stimulate inositol phosphate production in cultured human fibroblasts. FEBS Lett. 1990 Mar 12;262(1):111-4.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₅₀H₇₃N₁₅O₁₂

[ Molecular Weight ]:
1076.208

[ Exact Mass ]:
1075.556274

[ PSA ]:
434.01000

[ LogP ]:
-1.09

[ Index of Refraction ]:
1.700

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Bradykinin receptors and their antagonists.

Eur. J. Pharmacol. 348 , 1-10, (1998)

Bradykinin and related kinins act on two receptor types, named B1 and B2. Initially identified in classical bioassays, these receptors have been cloned and characterized in binding assays performed on...

Bradykinin receptor types and B2 subtypes.

Life Sci. 55 , 735-749, (1994)

Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characteriza...

Isolation and identification of hydroxyproline analogues of bradykinin in human urine.

FEBS Lett. 232 , 252, (1988)

Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine. Their amino acid se...