3’-Deoxy-3’-α-C-methyl-5-fluorouridine

Names

[ CAS No. ]:
37731-67-2

[ Name ]:
3’-Deoxy-3’-α-C-methyl-5-fluorouridine

[Synonym ]:
Uridine, 3'-deoxy-5-fluoro-3'-methyl-
3'-Deoxy-5-fluoro-3'-methyluridine

Biological Activity

[Description]:

3’-Deoxy-3’-α-C-methyl-5-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C10H13FN2O5

[ Molecular Weight ]:
260.22

[ Exact Mass ]:
260.080841

[ LogP ]:
-0.96

[ Index of Refraction ]:
1.593

Related Compounds