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DQP 1105

Names

[ CAS No. ]:
380560-89-4

[ Name ]:
DQP 1105

Biological Activity

[Description]:

DQP-1105 is a potent noncompetitive NMDA receptor antagonist. DQP-1105 inhibits GluN2C- and GluN2D-containing receptors (IC50=7.0 and 2.7 μM, respectively). The IC50 values are at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, GluA1-, or GluK2-containing receptors[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Acker TM, et al. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011;80(5):782-795.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H24BrN3O4

[ Molecular Weight ]:
558.42300

[ Exact Mass ]:
557.09500

[ PSA ]:
103.09000

[ LogP ]:
5.59430

[ Storage condition ]:
-20°C

Related Compounds