2-Mercaptopyridine N-oxide sodium

Names

[ Name ]:
2-Mercaptopyridine N-oxide sodium

[Synonym ]:
Sodium Pyrithione
1-Hydroxy-2-pyridinethione sodium salt
MFCD01941547
2-Mercaptopyridine-1-oxide sodium salt
Pyrithione sodium salt
1-hydroxy-2(1H)-pyridinethione sodium salt
Sodi
Sodium 2-pyridinethiolate 1-oxide
Sodium pyridine-2-thiolate 1-oxide
1-hydroxy-1,2-dihydropyridine-2-thione sodium salt
2-Mercaptopyridine-N-Oxide,Sodium Salt
1-hydroxy-1H-pyridine-2-thione sodium salt
NaPT
2-Pyridinethiol-1-oxide sodium salt
Sodium-2-pyridinethiol-1-oxide
Sodium pyrithione(NaPT)
2-Pyridinethiol, 1-oxide, sodium salt (1:1)
N-Hydroxypyridinethione Sodium Salt
thione(reagent)
2-Mercaptopyridine N-Oxide Sodium Salt
EINECS 223-296-5
PYRITHIONE SODIUM
Sodium pyrithion

Biological Activity

[Description]:

2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Debora L Campos, et al. Bactericidal Effect of pyridine-2-thiol 1-oxide Sodium Salt and Its Complex With Iron Against Resistant Clinical Isolates of Mycobacterium Tuberculosis. J Antibiot (Tokyo). 2020 Feb;73(2):120-124.

Chemical & Physical Properties

[ Density]:
1.22

[ Boiling Point ]:
109 °C

[ Melting Point ]:
-25 °C

[ Molecular Formula ]:
C₅H₄NNaOS

[ Molecular Weight ]:
149.146

[ Flash Point ]:
107.3ºC

[ Exact Mass ]:
148.991135

[ PSA ]:
25.46000

[ LogP ]:
1.02090

[ Water Solubility ]:
54.7 g/100 mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT9000000

CHEMICAL NAME :: 2-Pyridinethiol, N-oxide, sodium salt

CAS REGISTRY NUMBER :: 3811-73-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H5-N-O-S.Na

MOLECULAR WEIGHT :: 150.16

WISWESSER LINE NOTATION :: T6NJ AO BS &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 428 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04703

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,693,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9403 No. of Facilities: 1876 (estimated) No. of Industries: 40 No. of Occupations: 42 No. of Employees: 69571 (estimated) No. of Female Employees: 7591 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S26-S36-S24/25-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UT9000000

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections.

J. Virol. 83 , 58-64, (2009)

We have discovered two metal ion binding compounds, pyrithione (PT) and hinokitiol (HK), that efficiently inhibit human rhinovirus, coxsackievirus, and mengovirus multiplication. Early stages of virus...

Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.

Am. J. Respir. Cell. Mol. Biol. 41 , 69-75, (2009)

We recently reported that induction of metallothionein (MT) was critical in limiting nickel (Ni)-induced lung injury in intact mice. Nonetheless, the mechanism by which Ni induces MT expression is unc...

Functional alterations of human platelets following indium-111 labelling using different incubation media and labelling agents.

Eur. J. Nucl. Med. 18(5) , 326-31, (1991)

Human platelets were labelled in the absence or presence of plasma using indium-111 labelled oxine sulphate, tropolone or 2-mercaptopyridine-N-oxide (MPO). Under in vitro and in vivo conditions, plate...