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VRT-532

Names

[ CAS No. ]:
38214-71-0

[ Name ]:
VRT-532

[Synonym ]:
4-heptyl-2-(1(2)H-tetrazol-5-yl)-phenol
Phenol,4-heptyl-2-(1H-tetrazol-5-yl)
5-(2-hydroxy-5-methylphenyl)-3-phenylpyrazole
5-(2-hydroxy-5-heptylphenyl)tetrazole
3-(2-hydroxy-5-methylphenyl)-5-phenylpyrazole
5-(2-Hydroxy-5-heptylphenyl)tetrazol

Biological Activity

[Description]:

VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR
Research Areas >> Inflammation/Immunology

[In Vitro]

VRT-532 (15 µM) 直接结合重组的 G551D-CFTR 并改变其 ATP 酶活性[1]。

[References]

[1]. Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90.  

[2]. Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251.  

Chemical & Physical Properties

[ Density]:
1.213g/cm3

[ Boiling Point ]:
472.9ºC at 760 mmHg

[ Molecular Formula ]:
C16H14N2O

[ Molecular Weight ]:
250.29500

[ Flash Point ]:
239.8ºC

[ Exact Mass ]:
250.11100

[ PSA ]:
48.91000

[ LogP ]:
3.75770

[ Index of Refraction ]:
1.643

MSDS

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Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds