<Suppliers Price>

(Des-Gly10,Pro-NHEt9)-LHRH acetate salt

Names

[ CAS No. ]:
38234-21-8

[ Name ]:
(Des-Gly10,Pro-NHEt9)-LHRH acetate salt

[Synonym ]:
UNII:Q041AO6T91
Fertireline [inn-french]
[DES-GLY10] LH-RH,ETHYL AMIDE
fertirelin
Fertirelin [inn:ban]
Fertirelina [inn-spanish]
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt
5-oxo-Pro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-N-ethyl-
Fertireline
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NH-CH2-CH3
(DES-GLY10,PRO-NHET9)-LHRH
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
Fertirelina
Fertirelin Acetate

Biological Activity

[Description]:

Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others
Peptides

[In Vivo]

Fertirelin, an analog of GnRH 2.5 to 10 times more potent than native GnRH , has become the treatment of choice for reversing follicular cysts[1]. Administration of high doses of Fertirelin is found to reduce superovulatory responses[2].

[Animal admin]

Mice[2] Nulliparious female mice weighed 25-28 g (8-9 weeks) are used throughout the study. The mice are ddY strain and specific pathohen-free. As ovulation can be induced in mice at any time with administration of human chorionic gonadotrophin (hCG), 5.0 IU of hCG is injected subcutaneously into each mouse at 17:00, irrespective of the stage of the estrus cycle. This day is designated as Day 0. Nine groups are established according to the dose of Fertirelin ranging from 0.001 to 1.0 μg, and the administration are carried out at 22:00 on Day 0 and at 2:00, 6:00, 10:00 and 14:00 on Day 1[2].

[References]

[1]. Nakao T et al. Effect of fenprostalene 14 days after fertirelin treatment on intervals from treatment to conception in cows with follicular cysts diagnosed by milk progesterone test. J Vet Med Sci. 1993 Apr;55(2):207-10.

[2]. Nariai K, et al. Optimum dose of LH-RH analogue Fertirelin Acetate for the induction of superovulation in mice. Exp Anim. 2005 Jan;54(1):97-9.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C55H76N16O12

[ Molecular Weight ]:
1153.292

[ Exact Mass ]:
1152.582886

[ PSA ]:
429.04000

[ LogP ]:
-1.35

[ Index of Refraction ]:
1.698

[ Storage condition ]:
-15°C

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
60

[ Safety Phrases ]:
53-22-36/37/39-45

Related Compounds