Groenlandicine

Names

[ Name ]:
Groenlandicine

[Synonym ]:
Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium,11,12-dihydro-9-hydroxy-8-methoxy
Tetradehydrocheilanthiofolinium
Groenlandicine
Tetradehydrocheilanthifoline

Biological Activity

[Description]:

Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase I

[References]

[1]. Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12.

[2]. Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆NO₄+

[ Molecular Weight ]:
321.32700

[ Exact Mass ]:
321.10000

[ PSA ]:
48.64000

[ LogP ]:
1.44980

[ Storage condition ]:
2-8℃