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Furobufen

Names

[ CAS No. ]:
38873-55-1

[ Name ]:
Furobufen

[Synonym ]:
4-dibenzofuran-2-yl-4-oxo-butyric acid
Furobufenum [INN-Latin]
Furobufene [French]
Furobufeno [INN-Spanish]
Furobufen
Furobufeno [Spanish]
4-Dibenzofuran-2-yl-4-oxo-buttersaeure
Furobufene [INN-French]

Biological Activity

[Description]:

Furobufen, an anti-inflammatory agent, produces antiarthritic, antipyretic effects. Furobufen has an analgesic effect in inflamed tissue[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[In Vivo]

Furobufen (po; 10, 30, 90 mg/kg; once daily; 7 days) produces a dose-related inhibition of the paw edema produced by carrageenan in male rats weighing 180-200 g[1].

[References]

[1]. Martel RR, et al. Anti-inflammatory properties of furobufen. Can J Physiol Pharmacol. 1974 Jun;52(3):669-73.

Chemical & Physical Properties

[ Density]:
1.343g/cm3

[ Boiling Point ]:
509.8ºC at 760 mmHg

[ Molecular Formula ]:
C16H12O4

[ Molecular Weight ]:
268.26400

[ Flash Point ]:
262.1ºC

[ Exact Mass ]:
268.07400

[ PSA ]:
67.51000

[ LogP ]:
3.63350

[ Index of Refraction ]:
1.676

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP4930000
CHEMICAL NAME :
2-Dibenzofuranbutanoic acid, gamma-oxo-
CAS REGISTRY NUMBER :
38873-55-1
BEILSTEIN REFERENCE NO. :
0250326
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H12-O4
MOLECULAR WEIGHT :
268.28
WISWESSER LINE NOTATION :
T B656 HOJ DV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1283 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 52,669,1974

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%