<Suppliers Price>

Icariside D2

Names

[ CAS No. ]:
38954-02-8

[ Name ]:
Icariside D2

[Synonym ]:
p-(2'-hydroxyethyl)-phenol β-D-pyranoglucoside
2-(4'-β-D-glucopyranosyloxy)-phenylethanol
2-(4'-β-glucopyranosyloxy)phenylethanol
icariside D2
icariside D2
salidroside

Biological Activity

[Description]:

Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis [1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Research Areas >> Inflammation/Immunology

[In Vitro]

Icariside D2 3 induces apoptosis via alteration of expression of apoptosis-related proteins and decreases phosphorylation of AKT in HL-60 cells[1]. Icariside D2 exhibits anti-inflammatory and anti-HIV activity[3].

[References]

[1]. Nguyen Thi Thu Hien, et al. Chemical Constituents of the Annona Glabra Fruit and Their Cytotoxic Activity. Pharm Biol. 2015;53(11):1602-7.

[2]. Xue Liu, et al. Metabolic Engineering Escherichia coli for Efficient Production of Icariside D2. Biotechnol Biofuels. 2019 Nov 6;12:261.

[3]. Jin-YuLi, et al. Three new acylated prenylflavonol glycosides from Epimedium koreanum. Phytochemistry Letters Volume 17, September 2016, Pages 206-212.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H20O7

[ Molecular Weight ]:
300.30400

[ Exact Mass ]:
300.12100

[ PSA ]:
119.61000

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds