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EA4

Names

[ CAS No. ]:
389614-94-2

[ Name ]:
EA4

[Synonym ]:
7-Chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione
5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]-
ea4

Biological Activity

[Description]:

EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[Target]

Ki: 130 μM (rPLA2)[1]


[In Vitro]

EA4（9 μM，24 μM）抑制 rPLA2 和 cPLA2[1]。 EA4 可抑制 rPLA2，Ki 值为 130 μM[1]。 EA4 (50 μM) 以时间依赖性方式显著抑制 A23187 诱导的人和牛红细胞释放 AA[1]。

[References]

[1]. Shin, Hae Sook et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells. The Journal of biological chemistry vol. 277,23 (2002): 21086-94.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
508.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H17ClN2O2

[ Molecular Weight ]:
340.803

[ Flash Point ]:
261.2±30.1 °C

[ Exact Mass ]:
340.097870

[ PSA ]:
50.27000

[ LogP ]:
4.42

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.634

Related Compounds