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Ac-Glu-Glu-Val-Val-Ala-Cys-pNA

Names

[ CAS No. ]:
389868-12-6

[ Name ]:
Ac-Glu-Glu-Val-Val-Ala-Cys-pNA

[Synonym ]:
L-Cysteinamide, N-acetyl-L-α-glutamyl-L-α-glutamyl-L-valyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
N-Acetyl-L-α-glutamyl-L-α-glutamyl-L-valyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-cysteinamide

Biological Activity

[Description]:

Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. The sequence EEVVAC is derived from the 5A-5B cleavage junction of the HCV polyprotein[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease

[References]

[1]. Ede NJ, et al. Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein. J Pept Sci. 2000 Jan;6(1):11-8.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1289.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C34H50N8O13S

[ Molecular Weight ]:
810.872

[ Flash Point ]:
733.9±34.3 °C

[ Exact Mass ]:
810.321777

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.575

Related Compounds