CAY10760

Names

[ Name ]:
CAY10760

[Synonym ]:
2(1H)-Quinolinone, 6-chloro-3-[4,5-dihydro-5-(4-methoxyphenyl)-1-(1-oxopropyl)-1H-pyrazol-3-yl]-4-phenyl-
CAY10760
6-Chloro-3-[5-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-2(1H)-quinolinone

Biological Activity

[Description]:

Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC50=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> RAD51

[In Vitro]

Homologous recombination-IN-1 (10-40 μM; 5 h) reduces cell homologous recombination in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: BxPC3 cells Concentration: 10-40 μM Incubation Time: 5 hours Result: Led to homologous recombination inhibition with an EC50 value of 18.4 μM.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₂₄ClN₃O₃

[ Molecular Weight ]:
485.961

[ Exact Mass ]:
485.150604

[ LogP ]:
4.39

[ Index of Refraction ]:
1.660