ATV399

Names

[ Name ]:
ATV399

[Synonym ]:
1,3-Benzodioxole-5-carboxamide, N-[4-[[2-(3-pyridinyl)-1-piperidinyl]sulfonyl]phenyl]-
N-(4-{[2-(3-Pyridinyl)-1-piperidinyl]sulfonyl}phenyl)-1,3-benzodioxole-5-carboxamide

Biological Activity

[Description]:

ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS; inhibits cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose.

[References]

References 1. Zhong L, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14388. View Related Products by Target Nitric Oxide Synthase (NOS)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₂₃N₃O₅S

[ Molecular Weight ]:
465.522

[ Exact Mass ]:
465.135834

[ LogP ]:
3.00

[ Index of Refraction ]:
1.657