L(+)-Lysine monohydrate

Names

[ Name ]:
L(+)-Lysine monohydrate

[Synonym ]:
L-Lysine monohydrate
L-Lysine hydrate
lysine,hydrate
L-LYS H2O
LYS,MONOHYDRATE
EINECS 200-294-2
H-Lys-OH H2O
MFCD00151035

Biological Activity

[Description]:

L-Lysine hydrate is an essential amino acid. L-Lysine hydrate can be research for vascular calcification (VC) and acute pancreatitis[1][2].

[Related Catalog]:

Research Areas >> Others

Research Areas >> Inflammation/Immunology

[Target]

Microbial Metabolite

Human Endogenous Metabolite

[In Vitro]

L-Lysine hydrate (VSMCs) suppresses plasma iPTH and elevates plasma alanine, proline, plasma arginine, and homo arginine, thereby inhibiting apoptosis of VSMCs and mineral precipitation[1].

[In Vivo]

L-Lysine hydrate (40 μg/kg; p.o.) ameliorates arterial calcification in adenine rats and protects the femora from osteoporotic changes in adenine rats[1]. L-Lysine hydrate (10 and 400 mg/kg; i.g. and p.o.; Male mice) inhibits pancreatic tissue damage[2]. Animal Model: Male mice[2] Dosage: 10 and 400 mg/kg Administration: Intraperitoneal injection and oral administration; for 15 days Result: Inhibited the release of the inflammatory cytokine IL-6 and enhance antioxidant activity.

[References]

[1]. Shimomura A, et, al. Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65.

[2]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193.

Chemical & Physical Properties

[ Boiling Point ]:
400ºC at 760 mmHg

[ Melting Point ]:
212-214 °C

[ Molecular Formula ]:
C₆H₁₆N₂O₃

[ Molecular Weight ]:
164.20300

[ Flash Point ]:
195.7ºC

[ Exact Mass ]:
164.11600

[ PSA ]:
98.57000

[ LogP ]:
0.86360

[ Water Solubility ]:
>1500 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OL5540000

[ HS Code ]:
2922411000

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

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Nat. Commun. 5 , 5633, (2014)

The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevati...

A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties.

J. Biol. Chem. 255 , 976, (1980)

L-Lysine alpha-oxidase from Trichoderma viride Y244-2 has been purified to homogeneity. The enzyme shows absorption maxima at 277, 388, and 466 nm and a shoulder around 490 nm and contains 2 mol of FA...

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