WS-3

Names

[ Name ]:
WS-3

[Synonym ]:
N-Ethyl-p-menthane-3-carboxamide
N-ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
MFCD00130071
Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)-
N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
N-Ethyl 5-methyl-2-iso-propylcyclohexanecarboxamide
N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide
EINECS 254-599-0
WS-3

Biological Activity

[Description]:

WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

Research Areas >> Metabolic Disease

[Target]

EC50: 3.7 μM (TRPM8)[1]

[References]

[1]. Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.

[Related Small Molecules]

capsaicin | Capsazepine | EIPA | Diphenyleneiodonium chloride | HC-030031 | SKF-96365 | HC 067047 | AMG 9810 | GSK-1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG-517 | SB-366791 | IcilinAG-3-5

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
340.5±9.0 °C at 760 mmHg

[ Melting Point ]:
87-102 °C

[ Molecular Formula ]:
C₁₃H₂₅NO

[ Molecular Weight ]:
211.344

[ Flash Point ]:
205.7±3.7 °C

[ Exact Mass ]:
211.193619

[ PSA ]:
29.10000

[ LogP ]:
3.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.454

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S39-S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%