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Dehydrovomifoliol

Names

[ CAS No. ]:
39763-33-2

[ Name ]:
Dehydrovomifoliol

[Synonym ]:
(4S)-4-Hydroxy-3,5,5-trimethyl-4-[(1E)-3-oxo-1-buten-1-yl]-2-cyclohexen-1-one
(6S)-dehydrovomifoliol
2-Cyclohexen-1-one, 4-hydroxy-3,5,5-trimethyl-4-[(1E)-3-oxo-1-buten-1-yl]-, (4S)-
Dehydrovomifoliol

Biological Activity

[Description]:

Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Research Areas >> Metabolic Disease

[References]

[1]. MaJ, et al. Dehydrovomifoliol Alleviates Nonalcoholic FattyLiver Disease via the E2F1/AKT/mTOR Axis: Pharmacophore Modeling and MolecularDocking Study. Evid Based Complement Alternat Med. 2023 Feb 1;2023:9107598.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
367.4±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H18O3

[ Molecular Weight ]:
222.28

[ Flash Point ]:
190.2±24.4 °C

[ Exact Mass ]:
222.125595

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
2-8℃

Related Compounds