N-BUTYRYL-DL-HOMOCYSTEINE THIOLACTONE

Names

[ Name ]:
N-BUTYRYL-DL-HOMOCYSTEINE THIOLACTONE

[Synonym ]:
N-Butyryl-DL-homocysteine thiolactone
N-butyryl-L-Homocysteine thiolactone

Biological Activity

[Description]:

N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. N-Butyryl-DL-homocysteine thiolactone shows potential adverse effect and toxicity on bacteria. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Khalilzadeh P, et al. Growth inhibition of adherent Pseudomonas aeruginosa by an N-butanoyl-L-homoserine lactone analog. Can J Microbiol. 2010 Apr;56(4):317-25.

[2]. Iyer R, et al. Synthetic analogs of bacterial quorum sensors: US, US20110053890[P]. 2011-03-03.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₃NO₂S

[ Molecular Weight ]:
187.25900

[ Exact Mass ]:
187.06700

[ PSA ]:
74.96000

[ LogP ]:
1.77510

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
UN 3335

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures.

Cell. Mol. Neurobiol. 31 , 1221-1228, (2011)

Numerous studies have linked folate deficiency and resultant elevated plasma homocysteine levels with an increased risk of neurodegenerative diseases and seizures. The aim of the present study was to ...

Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones.

Microbiology 143 , 3703, (1997)

Quorum sensing relies upon the interaction of a diffusible signal molecule with a transcriptional activator protein to couple gene expression with cell population density. In Gram-negative bacteria, s...

[Effect of thiolactone homocysteine loading on adenosine metabolism in rats: relationship with platelet hyper-reactivity, correction of this metabolism disorders by vitamin-microelement complex].

Ukr. Biokhim. Zh. 82 , 59-66, (2010)

Influence of DL-homocysteine thiolactone loading (100 mg/kg by intragastric administration for 28 days) on enzymes activity of adenylic nucleotide and adenosine metabolism in the blood serum, platelet...