methyllinderone

Names

[ Name ]:
methyllinderone

[Synonym ]:
4,5-Dimethoxy-2-[(2E)-1-methoxy-3-phenyl-2-propen-1-ylidene]-4-cyclopentene-1,3-dione
Methyl-linderon
4-Cyclopentene-1,3-dione, 4,5-dimethoxy-2-[(2E)-1-methoxy-3-phenyl-2-propen-1-ylidene]-
Methyllinderone

Biological Activity

[Description]:

Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

Research Areas >> Inflammation/Immunology

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Yoon JH, et al. Methyl Linderone Suppresses TPA-Stimulated IL-8 and MMP-9 Expression Via the ERK/STAT3 Pathway in MCF-7 Breast Cancer Cells. J Microbiol Biotechnol. 2020 Mar 28;30(3):325-332.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
570.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆O₅

[ Molecular Weight ]:
300.31

[ Flash Point ]:
254.4±30.2 °C

[ Exact Mass ]:
300.099762

[ PSA ]:
61.83000

[ LogP ]:
1.45

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.570

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914190090

Customs

[ HS Code ]: 2914190090

[ Summary ]:
2914190090 other acyclic ketones without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%