Thalidomide-5-methyl

Names

[ CAS No. ]:
40313-92-6

[ Name ]:
Thalidomide-5-methyl

Biological Activity

[Description]:

Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₂N₂O₄

[ Molecular Weight ]:
272.26

Thalidomide-5-methyl

Names

Biological Activity

Chemical & Physical Properties

Related Compounds