ACTH (4-10)

Names

[ Name ]:
ACTH (4-10)

[Synonym ]:
Adrenalonium chloratum
adrenalon hydrochloride
Adrenone hydrochloride
ADRENALONE,HYDROCHLORIDE
Stryphnonasal
Kephrine hydrochloride
Epinephrine ketone hydrochloride
ADRENALONE HCL
Adrenocorticotropic Hormone (ACTH) (4-10), human

Biological Activity

[Description]:

Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Metabolic Disease

[Target]

Melanocortin 4 receptor[1]

[In Vitro]

Adrenocorticotropic Hormone (ACTH) (4-10), human (ACTH (4-10)) is the core sequence of all melanocortins and binds selectively to MC4-R. In humans, ACTH (4-10) enters the cerebral fluid compartment after intranasal application and leads to a decrease in total body fat after 6 weeks of continuous treatment[1].

[References]

[1]. Wellhöner P, et al. Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue. Int J Obes (Lond). 2012 May;36(5):703-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Molecular Formula ]:
C₄₄H₅₉N₁₃O₁₀S

[ Molecular Weight ]:
962.09

[ PSA ]:
183.70000

[ LogP ]:
9.43540

[ Vapour Pressure ]:
4.64E-09mmHg at 25°C

[ Index of Refraction ]:
1.547

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I).

Biochem. Biophys. Res. Commun. 290 , 844-850, (2002)

The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin r...

Sniffing neuropeptides: a transnasal approach to the human brain.

Nat. Neurosci. 5(6) , 514-6, (2002)

The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans.

J. Clin. Endocrinol. Metab. 86(3) , 1144-8, (2001)

The control of body fat is a prominent factor in human health. Animal studies have indicated a homeostatic central nervous system regulation of body fat with particular involvement of the melanocortin...