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Caspase-9 Inhibitor III

Names

[ CAS No. ]:
403848-57-7

[ Name ]:
Caspase-9 Inhibitor III

[Synonym ]:
Caspase-9 Inhibitor III
AC-LEHD-CMK

Biological Activity

[Description]:

Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Apoptosis >> Caspase

[Target]

Caspase-9


[In Vitro]

Caspase-9 Inhibitor III (0.07-0.105 μM; 灌注 10 min) 显着减弱 I/R 诱导的离体大鼠心脏梗塞大小的增加，冠状动脉废水中乳酸脱氢酶的释放和肌酸激酶的释放，以及凋亡指数[1]。 Caspase-9 Inhibitor III (30 μM) 抑制由 MMP-2 诱导的肌钙蛋白 I 水解[2]。

[References]

[1]. Sodhi RK, et, al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch Pharm Res. 2009 Jul;32(7):1037-43.  

[2]. Castro MM, et, al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem Pharmacol. 2013 Aug 15;86(4):469-75.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H35ClN6O9

[ Molecular Weight ]:
587.02

Related Compounds