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GSK3 Inhibitor XIII

Names

[ CAS No. ]:
404828-08-6

[ Name ]:
GSK3 Inhibitor XIII

[Synonym ]:
GSK3 Inhibitor XIII

Biological Activity

[Description]:

GSK-3 Inhibitor XIII is a potent and ATP-competitive GSK-3 inhibitor with a Ki of 24 nM[1][1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[References]

[1]. Albert C Pierce, et al. CH...O and CH...N hydrogen bonds in ligand design: a novel quinazolin-4-ylthiazol-2-ylamine protein kinase inhibitor. J Med Chem. 2005 Feb 24;48(4):1278-81.

[2]. Eduardo Cruz Moraes, et al. Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity. Molecules. 2015 Jan 13;20(1):1176-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅N₅

[ Molecular Weight ]:
301.34500

[ Exact Mass ]:
301.13300

[ PSA ]:
69.72000

[ LogP ]:
3.49380

[ Storage condition ]:
2-8°C

Related Compounds