m-PEG9-CH2COOH

Names

[ CAS No. ]:
405518-55-0

[ Name ]:
m-PEG9-CH2COOH

[Synonym ]:
2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-oic acid
3,6,9,12,15,18,21,24,27,30-DECAOXAHENTRIACONTANOIC ACID

Biological Activity

[Description]:

m-PEG9-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.122

[ Boiling Point ]:
557.372ºC at 760 mmHg

[ Molecular Formula ]:
C21H42O12

[ Molecular Weight ]:
486.55100

[ Flash Point ]:
175.904ºC

[ Exact Mass ]:
486.26800

[ PSA ]:
129.60000

Related Compounds