Sulisobenzone

Names

[ Name ]:
Sulisobenzone

[Synonym ]:
Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-
Benzophenone-4
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate
EINECS 223-772-2
Sulisobenzona
sulisobenzone
Sulisobenzone Hydrate
2-Hydroxy-4-Methoxy-5-sulfonylbenzophenone(BP-4)
Sulisobenzonum
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic Acid Hydrate
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid,HMBS,Sulisobenzone
MFCD00024962

Biological Activity

[Description]:

Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
0°C

[ Melting Point ]:
170 °C

[ Molecular Formula ]:
C₁₄H₁₂O₆S

[ Molecular Weight ]:
308.306

[ Flash Point ]:
0°C

[ Exact Mass ]:
308.035461

[ PSA ]:
109.28000

[ LogP ]:
0.89

[ Index of Refraction ]:
1.617

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB5044300

CHEMICAL NAME :: Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-

CAS REGISTRY NUMBER :: 4065-45-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H12-O6-S

MOLECULAR WEIGHT :: 308.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),35,1983 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3530 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),35,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3211 No. of Facilities: 7190 (estimated) No. of Industries: 58 No. of Occupations: 35 No. of Employees: 91292 (estimated) No. of Female Employees: 38820 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
DB5044300

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Altered UV absorbance and cytotoxicity of chlorinated sunscreen agents.

Cutan. Ocul. Toxicol. 31(4) , 273-9, (2012)

Sunscreens are widely utilized due to the adverse effects of ultraviolet (UV) radiation on human health. The safety of their active ingredients as well as that of any modified versions generated durin...

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

Nat. Commun. 5 , 4028, (2014)

Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's disease (PD) known ...

Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.

Mol. Cell. Biol. 35(4) , 675-87, (2015)

Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are nece...