(2R,3R,4R,5R)-2-(6-amino-2-methylsulfanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Names

[ Name ]:
(2R,3R,4R,5R)-2-(6-amino-2-methylsulfanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

[Synonym ]:
2-MeS-adenosine
S-methyl-2-thio-isoguanosine

Biological Activity

[Description]:

2-Methylthioadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.98g/cm3

[ Boiling Point ]:
747.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₅N₅O₄S

[ Molecular Weight ]:
313.33

[ Flash Point ]:
406ºC

[ Exact Mass ]:
313.08400

[ PSA ]:
164.84000

[ Index of Refraction ]:
1.878