toralactone

Names

[ Name ]:
toralactone

[Synonym ]:
Toralactone
9,10-dihydroxy-7-methoxy-3-methylbenzo[g]isochromen-1-one
9,10-Dihydroxy-7-methoxy-3-methyl-1H-naphtho(2,3-c)pyran-1-one
torolactone

Biological Activity

[Description]:

Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> NF-κB >> Keap1-Nrf2

[In Vitro]

Toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity[2].

[References]

[1]. YongtaekSeo, et al. Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism. Food Research International. Volume 97, July 2017, Pages 340-346.

[2]. Salwa D. Alqahtani, et al. Abstract 1205: Rubrofusarin and toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity. AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC.

Chemical & Physical Properties

[ Density]:
1.432g/cm3

[ Boiling Point ]:
480.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₂O₅

[ Molecular Weight ]:
272.25300

[ Flash Point ]:
184.8ºC

[ Exact Mass ]:
272.06800

[ PSA ]:
79.90000

[ LogP ]:
2.67440

[ Index of Refraction ]:
1.691

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%