O-Demethyl Lenvatinib

Names

[ Name ]:
O-Demethyl Lenvatinib

[Synonym ]:
6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-hydroxy-
4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-hydroxy-6-quinolinecarboxamide
4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-hydroxy-6-quinolinecarboxamide
Lenvatinib Impurity 4

Biological Activity

[Description]:

O-Demethyl Lenvatinib is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

[Related Catalog]:

Research Areas >> Cancer

Chemical & Physical Properties

[ Density]:
1.6±0.0 g/cm3

[ Boiling Point ]:
644.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₇ClN₄O₄

[ Molecular Weight ]:
412.826

[ Flash Point ]:
343.4±0.0 °C

[ Exact Mass ]:
412.093842

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.739

[ Water Solubility ]:
Insuluble (6.2E-5 g/L) (25 ºC)

O-Demethyl Lenvatinib

Names

Biological Activity

Chemical & Physical Properties

Related Compounds