SW155246

Names

[ CAS No. ]:
420092-79-1

[ Name ]:
SW155246

[Synonym ]:
4-Chloro-N-(4-hydroxy-1-naphthyl)-3-nitrobenzenesulfonamide
Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-
MFCD01165393
SW155246

Biological Activity

[Description]:

SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> DNA Methyltransferase

[References]

[1]. Jessica A Kilgore, et al. Identification of DNMT1 selective antagonists using a novel scintillation proximity assay. J Biol Chem. 2013 Jul 5;288(27):19673-84.

[2]. José L Medina-Franco, et al. Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking. Int J Mol Sci. 2014 Feb 21;15(2):3253-61.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
613.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₁ClN₂O₅S

[ Molecular Weight ]:
378.787

[ Flash Point ]:
324.6±34.3 °C

[ Exact Mass ]:
378.007721

[ LogP ]:
3.94

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.731

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport