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d [Leu4,Lys8] -VP TFA

Names

[ CAS No. ]:
42061-33-6

[ Name ]:
d [Leu4,Lys8] -VP TFA

[Synonym ]:
MPR-TYR-PHE-LEU-ASN-CYS-PRO-LYS-GLY-NH2
3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2

Biological Activity

[Description]:

D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
Research Areas >> Neurological Disease

[Target]

vasopressin V1b receptor[1]


[References]

[1]. Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46.

[2]. Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C47H67N11O11S2

[ Molecular Weight ]:
1026.23000

[ Exact Mass ]:
1025.45000

[ PSA ]:
407.04000

[ LogP ]:
2.97890

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds