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3'-Deoxy-3'-amino-ATP

Names

[ CAS No. ]:
4209-30-7

[ Name ]:
3'-Deoxy-3'-amino-ATP

[Synonym ]:
3'-Amino-3'-deoxy-ATP
3'-Amino-3'-desoxyadenosin-5'-triphosphat
3'-Amino-3'-deoxyadenosine 5'-triphosphate
3'-deoxy-3'-aminoadenosine 5'-triphosphate
O5'-(tetrahydroxy-[1]triphosphoryl)-3'-amino-3'-deoxy-adenosine

Biological Activity

[Description]:

3'-Deoxy-3'-amino-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a Ki of 2.3 μM. 3'-Deoxy-3'-amino-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

3'-Deoxy-3'-amino-ATP can be used as a substrate to synthesis of 3′-Amino-3′-deoxy transfer RNA[2].

[References]

[1]. Armstrong VW, et, al. Interaction of substrate analogues with Escherichia coli DNA-dependent RNA polymerase. Eur J Biochem. 1976 Nov 1;70(1):33-8.

[2]. Fraser TH, et, al. Synthesis and aminoacylation of 3'-amino-3'-deoxy transfer RNA and its activity in ribosomal protein synthesis. Proc Natl Acad Sci U S A. 1973 Sep;70(9):2671-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H17N6O12P3

[ Molecular Weight ]:
506.19600

[ Exact Mass ]:
506.01200

[ PSA ]:
314.35000

Related Compounds