[5-(6-aminopurin-9-yl)-3-hydroxy-oxolan-2-yl]methylimino-imino-azanium

Names

[ Name ]:
[5-(6-aminopurin-9-yl)-3-hydroxy-oxolan-2-yl]methylimino-imino-azanium

[Synonym ]:
5'-azido-2',5'-dideoxyadenosine
5'-azido-5'-deoxy-2',3'-O-isopropylideneguanosine
5'-azido-2',3'-O-isopropylideneguanosine
5'-azido-O2',O3'-isopropylidene-5'-deoxy-guanosine
5'-azido-5',2'-dideoxyadenosine
2',3'-O-Isopropyliden-5'-azido-5'-desoxy-guanosin

Biological Activity

[Description]:

5′-Azido-2′,5′-dideoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₂N₈O₂

[ Molecular Weight ]:
276.25

[ Exact Mass ]:
276.10800

[ PSA ]:
148.83000

[ LogP ]:
0.40116

[5-(6-aminopurin-9-yl)-3-hydroxy-oxolan-2-yl]methylimino-imino-azanium

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds