resveratrol triacetate

Names

[ Name ]:
resveratrol triacetate

[Synonym ]:
1,3-Benzenediol, 5-[(E)-2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate
3-Acetoxy-5-[(E)-2-(4-acetoxyphenyl)vinyl]phenyl acetate
5-[(1E)-2-[4-(acetyloxy)phenyl]ethenyl]-1,3-Benzenediol-1,3-diacetate
Acetyl trans-resveratrol
(E)-5-(4-Acetoxystyryl)-1,3-phenylene diacetate
Triacetyl resveratrol
3,4',5-Triacetoxy-trans-stilbene
Acetyl-trans-resveratrol
Acetic acid 4-[2-(3,5-diacetoxyphenyl)vinyl]phenyl ester
resveratrol triacetate
Acetyl-resveratrol

Biological Activity

[Description]:

Triacetylresveratrol, an acetylated analog of Resveratrol. Triacetylresveratrol decreases the phosphorylation of STAT3 and NF-κB in a dose- and time- dependent manner in PANC-1 and BxPC-3 cells. Anticancer effects[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

NF-κB

STAT3

[In Vitro]

Triacetylresveratrol significantly down-regulates anti-apoptotic Bcl-2 family protein Mcl-1 and up-regulates pro-apoptotic Bcl-2 family proteins Bim and Puma. Triacetylresveratrol inhibits cell viability, and induces apoptosis of pancreatic cancer cells in a concentration and incubation time-dependent manner[1].

[References]

[1]. Duan J, et al. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells.Sci Rep. 2016 Aug 19;6:31672.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
504.8±50.0 °C at 760 mmHg

[ Melting Point ]:
117.0 to 121.0 °C

[ Molecular Formula ]:
C₂₀H₁₈O₆

[ Molecular Weight ]:
354.353

[ Flash Point ]:
221.4±30.2 °C

[ Exact Mass ]:
354.110352

[ PSA ]:
78.90000

[ LogP ]:
2.94

[ Appearance of Characters ]:
white to tan

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
room temp

[ Water Solubility ]:
DMSO: ≥18mg/mL

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H318-H335-H400

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
37/38-41-43-50/53

[ Safety Phrases ]:
26-36/37/39-60-61

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%