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Tos-PEG6-OH

Names

[ CAS No. ]:
42749-28-0

[ Name ]:
Tos-PEG6-OH

[Synonym ]:
3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, mono(4-methylbenzenesulfonate)
17-Hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl 4-methylbenzenesulfonate

Biological Activity

[Description]:

Tos-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
555.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H32O9S

[ Molecular Weight ]:
436.517

[ Flash Point ]:
289.7±30.1 °C

[ Exact Mass ]:
436.176697

[ LogP ]:
-0.84

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.503

Related Compounds