Clopirac

Names

[ Name ]:
Clopirac

[Synonym ]:
1-p-Chlorphenyl-2,5-dimethyl-pyrrol-3-essigsaeure
CP 172AP
EINECS 255-938-5
CLOPIRAC

Biological Activity

[Description]:

Clopirac is a potent and orally active inhibitor of prostaglandin synthetase. Clopirac is an anti-inflammatory agent[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

[Target]

prostaglandin synthetase[1]

[References]

[1]. Roba J, et al. Etude pharmacologique d'un nouvel anti-inflammatoire non stéroïdien, le clopirac [Pharmacological study of clopirac, a new anti-inflammatory agent (author's transl)]. J Belge Rhumatol Med Phys. 1975;30 Spec no:3-24.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
429.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₄ClNO₂

[ Molecular Weight ]:
263.71900

[ Flash Point ]:
213.3ºC

[ Exact Mass ]:
263.07100

[ PSA ]:
42.23000

[ LogP ]:
3.37460

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9277490

CHEMICAL NAME :: 1H-Pyrrole-3-acetic acid, 1-(4-chlorophenyl)-2,5-dimethyl-

CAS REGISTRY NUMBER :: 42779-82-8

BEILSTEIN REFERENCE NO. :: 0480479

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H14-Cl-N-O2

MOLECULAR WEIGHT :: 263.74

WISWESSER LINE NOTATION :: T5NJ AR DG& B1 C1VQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 11,173,1976

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%