N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

Names

[ Name ]:
N-(3,4-dimethylisoxazol-5-yl)sulphanilamide, compound with 2,2'-iminodiethanol (1:1)

[Synonym ]:
NU-445
N-(3,4-Dimethylisoxazol-5-yl)sulphanilamide,compound with 2,2'-iminodiethanol (1:1)
Sulfafurazol 2,2'-imidodiethanol
Benzenesulfonamide,4-amino-N-(3,4-dimethyl-5-isoxazolyl)-,compd. with 2,2'-iminobis(ethanol) (1:1)
EINECS 224-308-1
N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide compound with 2,2'-iminodiethanol (1:1)
SULFISOXAZOLE DIOLAMINE
Sulfisoxazole diolamine (USAN)

Biological Activity

[Description]:

Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Endocrinology

Research Areas >> Infection

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

ETA:0.60 μM (IC50)

ETB:22 μM (IC50)

[References]

[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.

[2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.

Chemical & Physical Properties

[ Boiling Point ]:
482.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₄N₄O₅S

[ Molecular Weight ]:
372.44000

[ Flash Point ]:
245.4ºC

[ Exact Mass ]:
372.14700

[ PSA ]:
159.09000

[ LogP ]:
2.36090