tridihexethyl chloride

Names

[ Name ]:
tridihexethyl chloride

[Synonym ]:
(3-cyclohexyl-3-hydroxy-3-phenylpropyl)-triethylazanium,chloride
EINECS 224-323-3
Tridihexethyl chloride
(3-Cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammonium chloride
60-49-1 (Parent)
Pathilon chloride
3-cyclohexyl-N,N,N-triethyl-3-hydroxy-3-phenylpropan-1-aminium chloride
Tridihexethyl chloride (BAN)

Biological Activity

[Description]:

Tridihexethyl (Pathilon) chloride is an orally active anticholinergic agent and mAChR antagonist, shows activities of antimuscarinic and anticholinergic. Tridihexethyl chloride shows pronounced antispasmodic and antisecretory effects on the gastrointestinal tract. Tridihexethyl chloride can be used in studies of peptic ulcer disease and acquired nystagmus [1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Leigh RJ, et al. Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41.

[2]. Jabbari B, et al. ffectiveness of trihexyphenidyl against pendular nystagmus and palatal myoclonus: evidence of cholinergic dysfunction. Mov Disord. 1987;2(2):93-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₆ClNO

[ Molecular Weight ]:
353.97000

[ Exact Mass ]:
353.24900

[ PSA ]:
20.23000

[ LogP ]:
1.72510

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2923900090

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%