L-Arginine L-glutamate

Names

[ Name ]:
L-Arginine L-glutamate

[Synonym ]:
Arginine glutamate
EINECS 224-350-0
Glutargin
Argimate
L-Glutamic acid, compd. with L-arginine (1:1)
L-Arginine - L-glutamic acid (1:1)
L-Arginine glutamate
S(+)-2-Amino-5-guanidinopentanoic acid L-glutamate salt
Glutepar
L-Arginine L-glutamate
L-Glutamic Acid compd. with L-Arginine (1:1)
MFCD06408000
L-Arginine, compd. with L-glutamic acid (1:1)
Ginamate

Biological Activity

[Description]:

L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Microbial Metabolite

Human Endogenous Metabolite

[In Vivo]

L-Arginine L-glutamate (10-30 mg/kg, p.o.) dose-dependently promotes gastric emptying in rats. This effect is dependent on vagus nerve activation. Intragastric L-Arginine L-glutamate (3-30 mg/kg intragastrically) also dose-dependently enhances adaptive relaxation of rat stomachs.

[References]

[1]. Ikumi Ishibashi-Shiraishi, et al. L-Arginine L-Glutamate Enhances Gastric Motor Function in Rats and Dogs and Improves Delayed Gastric Emptying in Dogs. J Pharmacol Exp Ther. 2016 Nov;359(2):238-246.

Chemical & Physical Properties

[ Boiling Point ]:
409.1ºC at 760 mmHg

[ Melting Point ]:
191 - 192ºC

[ Molecular Formula ]:
C₁₁H₂₃N₅O₆

[ Molecular Weight ]:
321.330

[ Flash Point ]:
201.2ºC

[ Exact Mass ]:
321.164825

[ PSA ]:
225.84000

[ LogP ]:
0.51620

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Arginine glutamate improves healing of radiation-induced skin ulcers in guinea pigs.

Int. J. Radiat. Biol. 89(12) , 1108-15, (2013)

The increase in the incidence of the radiation-induced skin injury cases and the absence of standard treatments escalate the interest in finding new and effective drugs for these lesions. We studied t...

Effect of biotin on ammonia intoxication in rats and mice.

J. Gastroenterol. 30(3) , 351-5, (1995)

The effects of biotin on ammonia concentration in blood and brain were evaluated in hyperammonemic rats and mice. Rats were injected with 5 mmol/kg BW of ammonium acetate, and mice were injected with ...

Circular dichroism and ultraviolet resonance Raman indicate little Arg-Glu side chain α-helix peptide stabilization.

J. Phys. Chem. B 115(14) , 4234-43, (2011)

Electrostatic interactions between side chains can control the conformation and folding of peptides and proteins. We used circular dichroism (CD) and ultraviolet (UV) resonance Raman spectroscopy (UVR...