3,3-(p-Chlorobenzylideno)-bis-4-hydroksykumaryn [Polish]
Names
[ CAS No. ]:
4322-59-2
[ Name ]:
3,3-(p-Chlorobenzylideno)-bis-4-hydroksykumaryn [Polish]
[Synonym ]:
3,3'-((4-chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
PCBD
COUMARIN,3,3'-(p-CHLOROBENZYLIDENE)BIS(4-HYDROXY
3,3'-(4-chlorobenzylidene)-bis[4-hydroxycoumarin]
3,3'-(p-Chlorobenzylideno)-bis-4-hydroksykumaryn [Polish]
3,3'-(4-chlorophenylmethylene)-bis-4-hydroxycoumarin
3,3'-(p-Chlorobenzylidene)bis(4-hydroxycoumarin)
Chemical & Physical Properties
[ Density]:
1.575g/cm3
[ Boiling Point ]:
625.7ºC at 760 mmHg
[ Molecular Formula ]:
C25H15ClO6
[ Molecular Weight ]:
446.83600
[ Flash Point ]:
332.2ºC
[ Exact Mass ]:
446.05600
[ PSA ]:
100.88000
[ LogP ]:
5.14420
[ Index of Refraction ]:
1.742
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GN4978000
- CHEMICAL NAME :
- Coumarin, 3,3'-(p-chlorobenzylidene)bis(4-hydroxy-
- CAS REGISTRY NUMBER :
- 4322-59-2
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C25-H15-Cl-O6
- MOLECULAR WEIGHT :
- 446.85
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 820 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 158 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 221 mg/kg/7D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 110 mg/kg/11D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 17,163,1965
Safety Information
[ HS Code ]:
2932209090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932209090
[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%