(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID

Names

[ Name ]:
(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID

[Synonym ]:
(2R)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
Tryptophan,5-hydroxy-,D
D-5-HTP (D-2-Amino-3-(5-hydroxyindolyl)propionic acid
C11H12N2O3
5-Hydroxytryptophan D-form
HRP
D-Tryptophan,5-hydroxy
D-5-Hydroxytryptophan

Biological Activity

[Description]:

D-5-Hydroxytryptophan (D-5-HTP) is the D-isomers of 5-HTP, and can be isolated from DL-5-hydroxytryptophan by successive separations[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22.

Chemical & Physical Properties

[ Melting Point ]:
27ºC

[ Molecular Formula ]:
C₁₁H₁₂N₂O₃

[ Molecular Weight ]:
220.22500

[ Exact Mass ]:
220.08500

[ PSA ]:
99.34000

[ LogP ]:
1.52820

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN7050000

CHEMICAL NAME :: Tryptophan, 5-hydroxy-, D-

CAS REGISTRY NUMBER :: 4350-07-6

LAST UPDATED :: 199109

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H12-N2-O3

MOLECULAR WEIGHT :: 220.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

Safety Information

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
20/21-20/21/22-36/37/38-65

[ Safety Phrases ]:
26-36

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%