4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol

Names

[ Name ]:
4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol

[Synonym ]:
4.4'-Dimethyl-biphenyltetrol-(2.5.2'.5')
2.5.2'.5'-Tetraoxy-4.4'-dimethyl-diphenyl
2.5.2'.5'-Tetrahydroxy-4.4'-dimethyl-biphenyl
2.5.2'.5'-Tetraoxy-ditolyl-(4.4')
4,4'-dimethyl[1,1'-biphenyl]-2,2',5,5'-tetrol
4,4'-Dimethyl-biphenyl-2,5,2',5'-tetraol

Biological Activity

[Description]:

NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

NSC2805 has WWP2 inhibitory activity with an IC50 of 0.38 μM[1]. NSC2805 shows a significant reduction in activity for all three proteins (WWP2, WWP1 and Nedd4)[1]. NSC2805 can robustly inhibit WWP2-dependent PTEN ubiquitination[1].

[References]

[1]. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
501.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₄O₄

[ Molecular Weight ]:
246.25900

[ Flash Point ]:
248.2ºC

[ Exact Mass ]:
246.08900

[ PSA ]:
80.92000

[ LogP ]:
2.79280

[ Index of Refraction ]:
1.675

Safety Information

[ HS Code ]:
2906299090

Customs

[ HS Code ]: 2906299090

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%