CK 666

Names

[ Name ]:
CK 666

[Synonym ]:
2-fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide
CK-666

Biological Activity

[Description]:

CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1].

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex

Research Areas >> Others

[Target]

Arp2/3 complex[1]

[References]

[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇FN₂O

[ Molecular Weight ]:
296.33900

[ Exact Mass ]:
296.13200

[ PSA ]:
48.38000

[ LogP ]:
4.16270

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling.

J. Cell Sci. 128 , 3781-95, (2015)

Many important signalling cascades operate through specialized signalling endosomes, but a corresponding mechanism has as yet not been described for hematopoietic cytokine receptors. Based on live-cel...

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.

Nat. Commun. 6 , 8045, (2015)

Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical ...

PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.

J. Cell Biol. 210 , 753-69, (2015)

Branched actin critically contributes to membrane trafficking by regulating membrane curvature, dynamics, fission, and transport. However, how actin dynamics are controlled at membranes is poorly unde...