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JW 67

Names

[ CAS No. ]:
442644-28-2

[ Name ]:
JW 67

Biological Activity

[Description]:

JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

IC50: 1.17μM (Wnt signaling)[1]


[In Vitro]

JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin[1]. JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines[1]. JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM[1]. Western Blot Analysis[1] Cell Line: SW480 cells Concentration: 1 μM Incubation Time: 24 hours Result: Increased the AXIN2 expression. RT-PCR[1] Cell Line: SW480 cells Concentration: 10 or 25μM Incubation Time: 72 hours Result: Reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.

[References]

[1]. Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011;71(1):197-205.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H18N2O6

[ Molecular Weight ]:
394.37700

[ Exact Mass ]:
394.11600

[ PSA ]:
102.10000

[ LogP ]:
1.84680

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

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