2-AMINO-3-[METHYLTHIO]BUTYRIC ACID

Names

[ CAS No. ]:
443-80-1

[ Name ]:
2-AMINO-3-[METHYLTHIO]BUTYRIC ACID

[Synonym ]:
DL-4-Thiaisoleucine
DL-thiaisoleucine
4-Thiaisoleucine
2-Amino-3-methylmercapto-buttersaeure
MFCD00056745

Biological Activity

[Description]:

DL-4-Thiaisoleucine is an isoleucine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.202g/cm3

[ Boiling Point ]:
280.1ºC at 760 mmHg

[ Molecular Formula ]:
C₅H₁₁NO₂S

[ Molecular Weight ]:
149.21100

[ Flash Point ]:
123.2ºC

[ Exact Mass ]:
149.05100

[ PSA ]:
88.62000

[ LogP ]:
0.85010

[ Vapour Pressure ]:
0.00103mmHg at 25°C

[ Index of Refraction ]:
1.528

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Validation of isoleucine utilization targets in Plasmodium falciparum.

Proc. Natl. Acad. Sci. U. S. A. 108 , 1627-1632, (2011)

Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemog...

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.

ChemBioChem. 12 , 1881-1885, (2011)

Isopenicillin N synthase (IPNS) catalyses the synthesis of isopenicillin N (IPN), the biosynthetic precursor to penicillin and cephalosporin antibiotics. IPNS is a non-heme iron(II) oxidase that media...

Incorporation of amino acid analogs interferes with the processing of the asparagine-linked oligosaccharide of the MOPC-46B kappa light chain.

J. Biol. Chem. 257 , 9039-9042, (1982)

The incorporation of the leucine analog, beta-hydroxyleucine, or the isoleucine analog, 4-thiaisoleucine, into the MPOC-46B kappa chain interfered with the processing of the oligosaccharide moiety of ...