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S119-8

Names

[ CAS No. ]:
443639-96-1

[ Name ]:
S119-8

[Synonym ]:
N-(4-anilinophenyl)-4-tert-butylbenzamide
Benzamide, 4-(1,1-dimethylethyl)-N-[4-(phenylamino)phenyl]-
MFCD01121291
N-(4-Anilinophenyl)-4-(2-methyl-2-propanyl)benzamide

Biological Activity

[Description]:

S119-8 is a broad spectrum inhibitor of influenza A and B viruses.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[Target]

Influenza A and B[1]


[In Vitro]

S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM[1].

[References]

[1]. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.


[Related Small Molecules]

Baloxavir | Pimodivir | KIN1148 | Zanamivir | Arbidol HCl | Nucleozin | Theaflavin | Desaminotyrosine | Peramivir Trihydrate | RIG-1 modulator 1 | Rimantadine Hydrochloride | Sodium copper chlorophyllin | SP187 | Dehydroandrographolide | M2 ion channel blocker

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
447.3±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H24N2O

[ Molecular Weight ]:
344.449

[ Flash Point ]:
128.3±26.9 °C

[ Exact Mass ]:
344.188873

[ LogP ]:
4.66

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
2-8℃

Related Compounds